Stem Cell Research on Cardiology

The consensus now is that adult stem cells have modest, if any, advantage to cardiac function. Research shows that pluripotent stem cell-derived cardiomyocytes can design beating human heart muscle cells that both release the required signals and replace muscle lost to heart attack. Cardiovascular diseases are the leading cause of death with very limited therapeutic option in the developed countries. A major cause lies in the very restricted regenerative scope of terminally differentiated cardiomyocytes post injury – therefore novel approaches toward cardiac regenerative therapy is highly desired. Following injury oft he myocardium, resident cardiac fibroblasts, defining over 50% of the cells in the heart, start to proliferate and produce extracellular matrix, which will ultimately leads to fibrosis and heart failure. A large number of preclinical and clinical trials have defined stem cell therapy to be a promising therapeutic approach for the treatment of cardiovascular diseases.

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